Iatrogenic allogenesis and autoimmune diseases

Authors

  • Daniel Noriega-Rodríguez Departamento de Cirugía Plástica y Caumatología. Hospital Docente Clínico-Quirúrgico Miguel Enríquez. Universidad de Ciencias Médicas de La Habana. Cuba Author https://orcid.org/0000-0002-3262-9888
  • Jonathan Quisilema-Cadena Departamento de Cirugía Plástica y Caumatología. Hospital Docente Clínico-Quirúrgico Miguel Enríquez. Universidad de Ciencias Médicas de La Habana. Cuba Author https://orcid.org/0000-0003-0649-5609
  • Armando Sánchez Leal Departamento de Cirugía Plástica y Caumatología. Hospital Docente Clínico-Quirúrgico Miguel Enríquez. Universidad de Ciencias Médicas de La Habana. Cuba Author https://orcid.org/0000-0002-7407-9925
  • Fabián Camilo Clavijo García Departamento de Cirugía Plástica y Caumatología. Hospital Docente Clínico-Quirúrgico Miguel Enríquez. Universidad de Ciencias Médicas de La Habana. Cuba Author https://orcid.org/0009-0008-4321-0725
  • Lissette Cárdenas de Baños Departamento de Posgrado e Investigaciones. Universidad de Ciencias Médicas de La Habana. Cuba Author https://orcid.org/0000-0003-1084-5931
  • Sergio González-García Departamento de Posgrado e Investigaciones. Universidad de Ciencias Médicas de La Habana. Cuba Author https://orcid.org/0000-0002-2359-9656

DOI:

https://doi.org/10.56294/ri2024.72

Keywords:

iatrogenic allogenesis, molding substances, autoimmune diseases

Abstract

Introduction. Iatrogenic allogenesis is currently a public health problem due to the constant increase in cases, especially in underdeveloped countries. Objective. To characterize patients diagnosed with iatrogenic allogenesis. Methods. An observational, descriptive, cross-sectional study was conducted in 23 patients with a confirmed diagnosis of iatrogenic allogenesis. Adverse reactions, the appearance of autoimmune diseases, and their association with the type of substance injected were described. Results. Women aged 30-39 years, single, and with non-university education predominated. 48% of patients received the infiltration by stylists in beauty salons. The most common infiltration area was the face, and 39% of patients did not know the substance that was injected. Granulomatous reactions, generalized pain, and nodule formation predominated, associated with all the molding agents used and with injections in the face. Contour changes and asymmetry were associated with the use of silicones and biopolymers and were more common with injections in the face and buttocks. 47.8% of patients were diagnosed with autoimmune diseases, with vasculitis and systemic lupus erythematosus being the most common. 63.6% of those diagnosed with autoimmune diseases were infiltrated with substances of unknown type. Conclusions. Granulomatous reactions, generalized pain, and nodule formation predominated, along with the diagnosis of vasculitis and systemic lupus erythematosus; these were more frequently associated with the injection of substances of unknown origin and composition

References

1. Castro CM, Ríos CA, López CA, Ospina ML, Ortiz Y. Adverse effects of modeling substances in Cali, Colombia. Biomedica. 2021 Mar 19;41(1):123-130. English, Spanish. doi: 10.7705/biomedica.5707. PMID: 33761195; PMCID: PMC8055588.

2. Martínez-Villarreal AA, Asz-Sigall D, Gutiérrez-Mendoza D, Serena TE, Lozano-Platonoff A, Sanchez-Cruz LY, et al. A case series and a review of the literature on foreign modelling agent reaction: an emerging problem. Int Wound J. 2017. Jun;14(3):546–54. doi: 10.1111/iwj.12643

3. Corrales MF, Restrepo R, Calle E, Morales D. Biopolymer sarcoid-like foreign-body granulomas: Case report and literature review. Biomedica. 2022 May 1;42(Sp. 1):8-16. English, Spanish. doi: 10.7705/biomedica.6059. PMID: 35866725; PMCID: PMC9365448.

4. Croes C. Alogenosis Iatrogénica. Los Biopolimeros Atacan. Revista Salud, 2002; 2: 17-24.

5. Heidekrueger PI, Juran S, Ehrl D, Aung T, Tanna N, Broer PN. Global aesthetic surgery statistics: a closer look. J Plast Surg Hand Surg. 2017 Aug;51(4):270-274. doi: 10.1080/2000656X.2016.1248842. Epub 2016 Nov 15. PMID: 27844485.

6. Urdiales-Gálvez F, De Cabo-Francés FM, Bové I. Ultrasound patterns of different dermal filler materials used in aesthetics. J Cosmet Dermatol. 2021 May;20(5):1541-1548. doi: 10.1111/jocd.14032. Epub 2021 Mar 11. PMID: 33641224; PMCID: PMC8252486.

7. Martínez-Villarreal AA, Asz-Sigall D, Gutiérrez-Mendoza D, Serena TE, Lozano-Platonoff A, Sanchez-Cruz LY, Toussaint-Caire S, Domínguez-Cherit J, López-García LA, Cárdenas-Sánchez A, Contreras-Ruiz J. A case series and a review of the literature on foreign modelling agent reaction: an emerging problem. Int Wound J. 2017 Jun;14(3):546-554. doi: 10.1111/iwj.12643. Epub 2016 Aug 4. PMID: 27488810; PMCID: PMC7950136.

8. Alijotas-Reig J, Esteve-Valverde E, Gil-Aliberas N, Garcia-Gimenez V. Autoimmune/inflammatory syndrome induced by adjuvants-ASIA-related to biomaterials: analysis of 45 cases and comprehensive review of the literature. Immunol Res. 2018;66(1):120-140. doi:10.1007/s12026-017-8980-5

9. Domínguez A, Haddad J, Torres I, Jiménez G, Satré N, Espinosa S. Enfermedad por modelantes: problemática actual en México y presentación de casos. Cir Plást Iberolatinoam. 2013;39:399–405.

doi: 10.4321/S0376-78922013000400010 - DOI

10. Ricaurte AI, Forense M, Castaño DA, Castro JA, Paz DA De, Echeverry DA. Alogenosis iatrogénica vs alogenosis secundaria en Cali, Colombia. 2016;0684.

11. Gordillo-Hernández J, Alegre-Tamez E, Torres-Baltazar I, Mendieta-Espinosa M J, Sastré-Ortiz N. Abordaje multidisciplinario de la enfermedad humana por infiltraciónde sustancias modelantes. Cir. plást. iberolatinoam. [Internet]. 2013 Sep [citado 2021 Nov 18];39(3): 269-277. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0376- 78922013000300009&lng=es. https://dx.doi.org/10.4321/S0376-78922013000300009.

12. Coiffman F. Alogenosis iatrogénica: una nueva enfermedad. Cir Plást Iberolatinoam. 2008;34:1–10.

13. Colaris MJL, de Boer M, van der Hulst RR, Cohen Tervaert JW. Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature. Immunol Res. 2017 Feb;65(1):120-128. doi: 10.1007/s12026-016-8821-y. PMID: 27406737; PMCID: PMC5406475.

14. Chiang YZ, Pierone G, Al-Niaimi F. Dermal fillers: pathophysiology, prevention and treatment of complications. J Eur Acad Dermatol Venereol. 2017;31(3):405-413. doi:10.1111/jdv.13977

15. Dermal Fillers Soft tissue. FDA U.S FOOD & DRUG ADMINISTRATION. 26.10.2021. Disponible en: https://www.fda.gov/medical-devices/aesthetic-cosmetic-devices/dermal- fillers-soft-tissue-fillers

16. Israeli E, Agmon-Levin N, Blank M, Shoenfeld Y. Adjuvants and autoimmunity. Lupus. 2009;18(13):1217-1225. doi:10.1177/0961203309345724.

17. Alimoradi J, Novaa K. (Complications in connection with injection of dermal fillers). Ugeskrift for Laeger. 2019 Mar;181(12). PMID: 30931884. https://doi.org/10.1016/j.jdds.2016.01.001.

18. Sanz-Barriga Helen Amelia, Eróstegui Revilla Carlos Pedro. Alogenosis Iatrogénica,el Gran Peligro de los Biopolímeros. 2010; 13 (1): 31-34. Disponible en: http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1817- 74332010000100010&lng=es.

19. Lopez-Mendoza J, Vargas-Flores E, Mouneu-Ornelas N, Altamirano-Arcos C. Disease presentation and surgical treatment of patients with foreign-body granulomas and ASIA syndrome: case series. Arch Plast Surg. 2021 Jul;48(4):366-372. doi: 10.5999/aps.2020.02152. Epub 2021 Jul 15. PMID: 34352946; PMCID: PMC8342243.

20. Montealegre G, Uribe R, Martínez-Ceballos MA, Rojas-Villarraga A. ASIA syndrome symptoms induced by gluteal biopolymer injections: Case-series and narrative review. Toxicol Rep. 2021; 8:303-314. doi: 10.1016/j.toxrep.2021.01.011. PMID: 33552929; PMCID: PMC7856393

21. Seida I, Alrais M, Seida R, Alwani A, Kiyak Z, Elsalti A, Nil Esirgun S, Abali T, Mahroum N. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications. Clin Exp Immunol. 2023; 213(1):87-101. doi: 10.1093/cei/uxad033. PMID: 36881788; PMCID: PMC10324553

Downloads

Published

2024-08-26

How to Cite

1.
Noriega-Rodríguez D, Quisilema-Cadena J, Sánchez Leal A, Clavijo García FC, Cárdenas de Baños L, González-García S. Iatrogenic allogenesis and autoimmune diseases. Interdisciplinary Rehabilitation / Rehabilitacion Interdisciplinaria [Internet]. 2024 Aug. 26 [cited 2024 Dec. 22];4:.72. Available from: https://ri.ageditor.ar/index.php/ri/article/view/72